【药物名称】Azithromycin, DCH3, XZ-450, CP-62993, Zentavion, Toraseptol, Vinzam, Zithromac, Zitromax Avium 600, Zitromax, Zithromax, Sumamed
化学结构式(Chemical Structure):
参考文献No.8631
标题:N-Methyl 11-aza-10-deoxo-10-dihydroerythromycin A, intermediates therefor
作者:Bright, G.M. (Pfizer Inc.)
来源:EP 0101186; JP 1193292; US 4474768
合成路线图解说明:

This compound can be obtained by two different ways: 1) The oxidation of 9-deoxo-9a-aza-9a-homoerythromycin A (I) with 30% H2O2 in methanol gives the N-hydroxy-9-deoxo-9a-aza-9a-homoerythromycin A N'-oxide (II), which is methylated with ICH3 and K2CO3 in dichloromethane to afford N-methyl-9-deoxo-9a-aza-9a-homoerythromycin A bis(N-oxide) (III). Finally, this compound is reduced with H2 over Pd/C in ethanol. 2) By methylation of 9-deoxo-9a-aza-9a-homoerythromycin A (I) with formaldehyde and formic acid in CHCl3.

参考文献No.9835
标题:11-Methyl-11-aza-4-O-cladinosyl-6-O-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one and derivatives thereof
作者:Djokic, S.; Kobrehel, G. (Pliva Pharmaceutical, Chem., Food & Cosmetic Ind., Inc.)
来源:BE 0892357
合成路线图解说明:

This compound can be obtained by two different ways: 1) The oxidation of 9-deoxo-9a-aza-9a-homoerythromycin A (I) with 30% H2O2 in methanol gives the N-hydroxy-9-deoxo-9a-aza-9a-homoerythromycin A N'-oxide (II), which is methylated with ICH3 and K2CO3 in dichloromethane to afford N-methyl-9-deoxo-9a-aza-9a-homoerythromycin A bis(N-oxide) (III). Finally, this compound is reduced with H2 over Pd/C in ethanol. 2) By methylation of 9-deoxo-9a-aza-9a-homoerythromycin A (I) with formaldehyde and formic acid in CHCl3.

参考文献No.62384
标题:Azithromycin
作者:Casta馿r, J.; Serradell, M.N.
来源:Drugs Fut 1988,13(1),9
合成路线图解说明:

This compound can be obtained by two different ways: 1) The oxidation of 9-deoxo-9a-aza-9a-homoerythromycin A (I) with 30% H2O2 in methanol gives the N-hydroxy-9-deoxo-9a-aza-9a-homoerythromycin A N'-oxide (II), which is methylated with ICH3 and K2CO3 in dichloromethane to afford N-methyl-9-deoxo-9a-aza-9a-homoerythromycin A bis(N-oxide) (III). Finally, this compound is reduced with H2 over Pd/C in ethanol. 2) By methylation of 9-deoxo-9a-aza-9a-homoerythromycin A (I) with formaldehyde and formic acid in CHCl3.

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