Ipsapirone, Bay-q-7821(hydrochloride), TVX-Q-7821(hydrochloride)-药物合成数据库

【药物名称】Ipsapirone, Bay-q-7821(hydrochloride), TVX-Q-7821(hydrochloride)

化学结构式(Chemical Structure):

参考文献No.	2273
标题:	2-pyrimidinyl-1-piperazine derivatives, proceses for their preparation and medicaments containing them
作者:	Seidel, P.-R.; Horstmann, H.; Traber, J.; Dompert, W.; Glaser, T.; Schuurman, T. (Troponwerke GmbH & Co KG)
来源:	EP 0129128; JP 60023373; US 4818756; US 4937343; US 4988809

合成路线图解说明: The reaction of benzoisothiazole-3(2H)-one-1,1-dioxide (I) with 1,4-dibromobutane (II) by means of NaH in DMF gives 2-(4-bromobutyl)benzoisothiazole-3(2H)-one-1,1-dioxide (III), which is then condensed with 1-(2 pyrimidinyl)piperazine (IV) by means of K2CO3 in refluxing chlorobenzene.

参考文献No.	66395
标题:	Ipsapirone
作者:	Casta馿r, J.; Prous, J.
来源:	Drugs Fut 1986,11(7),565

合成路线图解说明: The reaction of benzoisothiazole-3(2H)-one-1,1-dioxide (I) with 1,4-dibromobutane (II) by means of NaH in DMF gives 2-(4-bromobutyl)benzoisothiazole-3(2H)-one-1,1-dioxide (III), which is then condensed with 1-(2 pyrimidinyl)piperazine (IV) by means of K2CO3 in refluxing chlorobenzene.