【药物名称】Ilepcimide, Antiepilepsirine
化学结构式(Chemical Structure):
参考文献No.105734
标题:Structure-anticonvulsant activity relationships of some cinnamamides of substituted aromatic ring
作者:Wang, S.; Li, R.; Liu, W.; et al.
来源:Acta Pharm Sin 1986,21(7),542-5
合成路线图解说明:

3,4-Methylenedioxycinnamic acid (I) is transformed into the corresponding acid chloride (II) by treatment with oxalyl chloride in benzene. The acid chloride is then converted without purification into antiepilepsirine by treatment with piperidine in benzene.

参考文献No.105735
标题:Pharmacological study of tablettae antiepilepticae I. Its effect on the CNS
作者:Pei, Y.; Li, J.; Cai, Z.; Zhang, B.; Ku, B.
来源:Nat Med J China 1978,58(4),216-9
合成路线图解说明:

3,4-Methylenedioxycinnamic acid (I) is transformed into the corresponding acid chloride (II) by treatment with oxalyl chloride in benzene. The acid chloride is then converted without purification into antiepilepsirine by treatment with piperidine in benzene.

参考文献No.120813
标题:ANTIEPILEPSIRINE
作者:Ruyun, J.
来源:Drugs Fut 1990,15(4),331
合成路线图解说明:

3,4-Methylenedioxycinnamic acid (I) is transformed into the corresponding acid chloride (II) by treatment with oxalyl chloride in benzene. The acid chloride is then converted without purification into antiepilepsirine by treatment with piperidine in benzene.

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