The reaction of 4-(3-hydroxy-3-methylbutyl)benzoic acid (I) with HCN in acetic acid-H2SO4 gives 4-[3-(formylamino)-3-methyibutylbenzoic acid (II), which is hydrolyzed to the corresponding amine (III) with aqueous HCl at 100 C. The reaction of benzoic acid (III) with SOCl2 gives the corresponding acyl chloride (IV), which by reaction with NH3 is converted to the benzamide (V). Finally, this compound is condensed with styrene oxide (VI) by means of hexamethyldisylazane in DMSO and hydrolyzed with NaOH in butanone water.

The reaction of 4-(3-hydroxy-3-methylbutyl)benzoic acid (I) with HCN in acetic acid-H2SO4 gives 4-[3-(formylamino)-3-methyibutylbenzoic acid (II), which is hydrolyzed to the corresponding amine (III) with aqueous HCl at 100 C. The reaction of benzoic acid (III) with SOCl2 gives the corresponding acyl chloride (IV), which by reaction with NH3 is converted to the benzamide (V). Finally, this compound is condensed with styrene oxide (VI) by means of hexamethyldisylazane in DMSO and hydrolyzed with NaOH in butanone water.

The reaction of 4-(3-hydroxy-3-methylbutyl)benzoic acid (I) with HCN in acetic acid-H2SO4 gives 4-[3-(formylamino)-3-methyibutylbenzoic acid (II), which is hydrolyzed to the corresponding amine (III) with aqueous HCl at 100 C. The reaction of benzoic acid (III) with SOCl2 gives the corresponding acyl chloride (IV), which by reaction with NH3 is converted to the benzamide (V). Finally, this compound is condensed with styrene oxide (VI) by means of hexamethyldisylazane in DMSO and hydrolyzed with NaOH in butanone water.