Bitolterol mesylate, WIN-32784, S-1540, Asmalene, Produrol, Tornalate-药物合成数据库

【药物名称】Bitolterol mesylate, WIN-32784, S-1540, Asmalene, Produrol, Tornalate

化学结构式(Chemical Structure):

参考文献No.	55731
标题:	Bitolterol
作者:	Casta馿r, J.; Weetman, D.F.
来源:	Drugs Fut 1976,1(10),454

合成路线图解说明: The reaction of 3,4-dihydroxyphenyl-tert-butylaminomethyl ketone (I) with sodium ethoxide in DMF gives the corresponding disodium salt, which without isolation is condensed with p-toluyl chloride (A) to yield 3,4-bis(p-toluyloxy)phenyl-tert-butylaminomethyl ketone hydrochloride (II); this salt is then reduced with H2 over Pd/C in ethanol or with sodium borohydride in methanol.

参考文献No.	701132
标题:	Ester von alpha-Aminomethyl-3-(hydroxy- oder hydroxymethyl)-4-hydroxybenzyl-alkoholen und Verfahren zu ihrer Herstellung
作者:	Minatoya, H.; et al.
来源:	DE 2015573; FR 2042295; GB 1298771

合成路线图解说明: The reaction of 3,4-dihydroxyphenyl-tert-butylaminomethyl ketone (I) with sodium ethoxide in DMF gives the corresponding disodium salt, which without isolation is condensed with p-toluyl chloride (A) to yield 3,4-bis(p-toluyloxy)phenyl-tert-butylaminomethyl ketone hydrochloride (II); this salt is then reduced with H2 over Pd/C in ethanol or with sodium borohydride in methanol.