The Grignard reaction of 4-(beta-diethylaminoethoxy)benzophenone (I) with benzylmagnesium chloride (II) yields the diphenyl benzyl carbinol (III), which is dehydrated to the ethylene (IV) by treatment with HCl in refluxing ethanol. The reaction of (IV) first with N-chlorosuccinimide (V) and then with K2CO3 affords a mixture of cis- and trans-1-[p-(beta-diethylaminoethoxy)phenyl]-1,2-diphenylchloroethylene (VI), which by treatment with citric acid (VII) is converted into the corresponding citrate (VIII) (1). Finally this compound is treated with binaphthyl-phosphoric acid (IX) in methanol in order to separate cis and trans isomers (2).

The Grignard reaction of 4-(beta-diethylaminoethoxy)benzophenone (I) with benzylmagnesium chloride (II) yields the diphenyl benzyl carbinol (III), which is dehydrated to the ethylene (IV) by treatment with HCl in refluxing ethanol. The reaction of (IV) first with N-chlorosuccinimide (V) and then with K2CO3 affords a mixture of cis- and trans-1-[p-(beta-diethylaminoethoxy)phenyl]-1,2-diphenylchloroethylene (VI), which by treatment with citric acid (VII) is converted into the corresponding citrate (VIII) (1). Finally this compound is treated with binaphthyl-phosphoric acid (IX) in methanol in order to separate cis and trans isomers (2).

The Grignard reaction of 4-(beta-diethylaminoethoxy)benzophenone (I) with benzylmagnesium chloride (II) yields the diphenyl benzyl carbinol (III), which is dehydrated to the ethylene (IV) by treatment with HCl in refluxing ethanol. The reaction of (IV) first with N-chlorosuccinimide (V) and then with K2CO3 affords a mixture of cis- and trans-1-[p-(beta-diethylaminoethoxy)phenyl]-1,2-diphenylchloroethylene (VI), which by treatment with citric acid (VII) is converted into the corresponding citrate (VIII) (1). Finally this compound is treated with binaphthyl-phosphoric acid (IX) in methanol in order to separate cis and trans isomers (2).