Epinastine-药物合成数据库

【药物名称】Epinastine

化学结构式(Chemical Structure):

参考文献No.	4501
标题:	Fused dibenzo imidazolo compounds, compositions and use
作者:	Walther, G.; Schneider, C.S,, Weber, K.-H.; Fuegner, A. (Boehringer Ingelheim GmbH)
来源:	DE 3008944

合成路线图解说明: By cyclization of 6-(aminomethyl)-6,11-dihydro-5H-dibenz[b,e]azepine (I) with cyanogen bromide (II) in THF, followed by a treatment with NaOH and acidification with HCl in ether.

参考文献No.	62377
标题:	Epinastine Hydrochloride
作者:	Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1987,12(12),1106

合成路线图解说明: By cyclization of 6-(aminomethyl)-6,11-dihydro-5H-dibenz[b,e]azepine (I) with cyanogen bromide (II) in THF, followed by a treatment with NaOH and acidification with HCl in ether.