Y-20811-药物合成数据库

【药物名称】Y-20811

化学结构式(Chemical Structure):

参考文献No.	6165
标题:	Imidazole derivative
作者:	Mineo, T. (Welfide Corporation)
来源:	JP 1986277670

合成路线图解说明: The reaction of 4-(5-iodo-2-methylbenzoyl)-3,5-dimethylbenzoic acid (I) with imidazole (II) by means of K2CO3, KF and Cu in DMF at 135 C gives 4-[5-(1-imidazolyl)-2-methylbenzoyl]-3,5-dimethylbenzoic acid (III), which is then reduced with NaBH4 in hot aqueous NaOH.

参考文献No.	72706
标题:	Y-20811
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1988,13(11),970

合成路线图解说明: The reaction of 4-(5-iodo-2-methylbenzoyl)-3,5-dimethylbenzoic acid (I) with imidazole (II) by means of K2CO3, KF and Cu in DMF at 135 C gives 4-[5-(1-imidazolyl)-2-methylbenzoyl]-3,5-dimethylbenzoic acid (III), which is then reduced with NaBH4 in hot aqueous NaOH.