【药物名称】FR-66973, FK-973
化学结构式(Chemical Structure):
参考文献No.3562
标题:New tetracyclo cpds., a process for their production and a pharmaceutical compsn. containing the same
作者:Kohsaka, M.; Terano, H.; Komori, T.; Iwami, M.; Yamashita, M.; Hashimoto, M.; Uchida, I.; Takase, S. (Fujisawa Pharmaceutical Co., Ltd.)
来源:AU 8543728; EP 0166389; ES 8703477; ES 8707961; ES 8707962; JP 1986010590; JP 1989199975; JP 1995067623; US 4645765; US 4861774
合成路线图解说明:

By acetylation of 8-carbamoyloxymethyl-5-formyl-7,9-dihydroxy-3,9-epoxy-1,1a,2,8,9,9a-octahydroazirino[2,3-c][1]benzazocine (FR-900482) (I) with acetic anhydride - pyridine.

合成路线图解说明:

FR-900482 (I) was produced by culturing Streptomyces sandaensis No. 6897 (FERM P-7654) and recovered by conventional methods. The acetylation of (I) with acetic anhydride gave the triacetyl derivative (II), which was selectively deacetylated with NaHCO3 in cool methanol yielding the diacetate (III). Finally, this compound was methylated by means of methyl iodide and K2CO3 in warm acetone.

参考文献No.79248
标题:FK-973
作者:Hoshi, A.; Prous, J.; Casta馿r, J.
来源:Drugs Fut 1989,14(2),119
合成路线图解说明:

By acetylation of 8-carbamoyloxymethyl-5-formyl-7,9-dihydroxy-3,9-epoxy-1,1a,2,8,9,9a-octahydroazirino[2,3-c][1]benzazocine (FR-900482) (I) with acetic anhydride - pyridine.

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