【药物名称】MPTP
化学结构式(Chemical Structure):
参考文献No.41893
标题:Certain 2,6-methano-3-benzazocines
作者:Block, F.B.; et al. (Novartis Corp.)
来源:US 3341538
合成路线图解说明:

The reaction of N-methyl-4-piperidone (II) with phenyllithium (I) in benzene-ethyl ether below 10 C gives 4-hydroxy-1-methyl-4.phenypiperidine (III), which is dehydrated by treating with refuxing concentrated HCl.

参考文献No.41894
标题:Nouveaux benzomorphanes et leur pr閜aration
作者:Frank, M.; Clarke, H.Jr. (Novartis Corp.)
来源:DE 1445845; DE 1795599; FR 1440638; FR 4024M; GB 1050227; US 3320265
合成路线图解说明:

The reaction of N-methyl-4-piperidone (II) with phenyllithium (I) in benzene-ethyl ether below 10 C gives 4-hydroxy-1-methyl-4.phenypiperidine (III), which is dehydrated by treating with refuxing concentrated HCl.

参考文献No.54319
标题:MPTP
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1986,11(5),384
合成路线图解说明:

N-Benzyl 2-aminoethanethiol (I) is reacted with 1,1-bis(methylsulfanyl)-2-nitroethene (II) in boiling ethanol to give RGH-5981.

合成路线图解说明:

The reaction of N-methyl-4-piperidone (II) with phenyllithium (I) in benzene-ethyl ether below 10 C gives 4-hydroxy-1-methyl-4.phenypiperidine (III), which is dehydrated by treating with refuxing concentrated HCl.

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