【药物名称】Pamicogrel, TO-192, KBT-3022, KB-3022, Paminate
化学结构式(Chemical Structure):
参考文献No.3327
标题:Novel 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazoles, process for the preparation thereof and pharmaceutical compsn. containing the same
作者:Yoshino, K.; Seko, N.; Yokota, K.; Ito, K.; Tsukamoto, G. (Kanebo Pharmaceuticals, Ltd.)
来源:EP 0159677; JP 1985222481; JP 1986033186; JP 1986200985; US 4659726
合成路线图解说明:

The cyclization of alpha-bromo-4,4'-dimethoxidesoxybenzoin (I) with pyrrole-2-carbothioamide (II) in hot acetonitrile gives 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazole (III), which is then condensed with ethyl bromoacetate (IV) by means of NaOH and tetrabutylammonium bromide in refluxing dichloromethane - water.

参考文献No.130589
标题:KBT-3022
作者:Prous, J.; Casta馿r, J.
来源:Drugs Fut 1991,16(2),105
合成路线图解说明:

The cyclization of alpha-bromo-4,4'-dimethoxidesoxybenzoin (I) with pyrrole-2-carbothioamide (II) in hot acetonitrile gives 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazole (III), which is then condensed with ethyl bromoacetate (IV) by means of NaOH and tetrabutylammonium bromide in refluxing dichloromethane - water.

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