【药物名称】Minoxidil, TM-160, U-10858, Minoximen, Neoxidil, RiUP, Loniten, Rogaine, Regaine
化学结构式(Chemical Structure):
参考文献No.800620
标题:Minoxidil
作者:Casta馿r, J.; Sungurbey, J.
来源:Drugs Fut 1977,2(6),383
合成路线图解说明:

Compound can be prepared in tvvo different ways both starting from 2,4-diamino-6-chloropyrimidine (I): 1) The oxidation of (I) with m-chloroperbenzoic acid in alcohol gives 6-amino-4-chloro-1,2-dihydro-1-hydroxy-2-iminopyrimidine (II), which is then condensed with refluxing piperidine. 2) A mixture of (I), 2,4-dichlorophenol (A) and KOH was heated at 150 C to give 2,4-diamino-6-(2,4-dichlorophenoxy)pyrimidine (III), which is oxidized with m-chloroperbenzoic acid in alcohol giving 6-amino-4-(2,4-dichlorophenoxy)-1,2-dihydro-1-hydroxy-2-iminopyrimidine (IV). Finally, this product is treated with piperidine at 150 C.

参考文献No.800621
标题:N-Alkyl pyrrolidone-plasticized copolylactam compositions
作者:Hyde, T.J.
来源:US 3644264
合成路线图解说明:

Compound can be prepared in tvvo different ways both starting from 2,4-diamino-6-chloropyrimidine (I): 1) The oxidation of (I) with m-chloroperbenzoic acid in alcohol gives 6-amino-4-chloro-1,2-dihydro-1-hydroxy-2-iminopyrimidine (II), which is then condensed with refluxing piperidine. 2) A mixture of (I), 2,4-dichlorophenol (A) and KOH was heated at 150 C to give 2,4-diamino-6-(2,4-dichlorophenoxy)pyrimidine (III), which is oxidized with m-chloroperbenzoic acid in alcohol giving 6-amino-4-(2,4-dichlorophenoxy)-1,2-dihydro-1-hydroxy-2-iminopyrimidine (IV). Finally, this product is treated with piperidine at 150 C.

参考文献No.800622
标题:6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-phenoxypyrimidines
作者:Anthony, W.C.; et al.
来源:CH 495361; DE 1795837; FR 1510017; GB 1167736; US 3382247; US 3382248; US 3461461
合成路线图解说明:

Compound can be prepared in tvvo different ways both starting from 2,4-diamino-6-chloropyrimidine (I): 1) The oxidation of (I) with m-chloroperbenzoic acid in alcohol gives 6-amino-4-chloro-1,2-dihydro-1-hydroxy-2-iminopyrimidine (II), which is then condensed with refluxing piperidine. 2) A mixture of (I), 2,4-dichlorophenol (A) and KOH was heated at 150 C to give 2,4-diamino-6-(2,4-dichlorophenoxy)pyrimidine (III), which is oxidized with m-chloroperbenzoic acid in alcohol giving 6-amino-4-(2,4-dichlorophenoxy)-1,2-dihydro-1-hydroxy-2-iminopyrimidine (IV). Finally, this product is treated with piperidine at 150 C.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us