SDZ-89-485-药物合成数据库

【药物名称】SDZ-89-485

化学结构式(Chemical Structure):

参考文献No.	65832
标题:	Synthesis and structure-activity relationships of SDZ 89-485 and analogues
作者:	Meingassner, J.G.; Grassberger, M.A.; Schaub, F.
来源:	Xth Cong Int Soc Human Animal Mycol (Barcelona) 1988,Abst P-153

合成路线图解说明: Reaction of 1-(4-chlorophenyl)-2-cyclopropyl-2-methyl-1-propanone (I) with lithiated (R)-1-methyl-4-(methylsulfinyl)benzene gives a 3:2 mixture of RR and SR addition product (II), which is separated by chromatography. The RR-diastereomer is reduced with acetyl chloride-sodium iodide in acetone and the resulting thioether (III) is cyclized to the oxirane (IV) by alkylation with triethyloxonium-tetrafluoroborate, followed by treatment with sodium hydroxide. Opening the oxirate with triazole in DMF in the presence of potassium carbonate and 18-crown-6 gives SDZ 89-485.

参考文献No.	103337
标题:	SDZ 89-485
作者:	Grassberger, M.A.
来源:	Drugs Fut 1989,14(8),772

合成路线图解说明: Reaction of 1-(4-chlorophenyl)-2-cyclopropyl-2-methyl-1-propanone (I) with lithiated (R)-1-methyl-4-(methylsulfinyl)benzene gives a 3:2 mixture of RR and SR addition product (II), which is separated by chromatography. The RR-diastereomer is reduced with acetyl chloride-sodium iodide in acetone and the resulting thioether (III) is cyclized to the oxirane (IV) by alkylation with triethyloxonium-tetrafluoroborate, followed by treatment with sodium hydroxide. Opening the oxirate with triazole in DMF in the presence of potassium carbonate and 18-crown-6 gives SDZ 89-485.