【药物名称】Carbisocaine hydrochloride, Carbizocaine hydrochloride, BK 95
化学结构式(Chemical Structure):
参考文献No.53863
标题:Carbizocaine hydrochloride
作者:R醖i, S.
来源:Drugs Fut 1986,11(7),555
合成路线图解说明:

Reaction of 1,2-epoxypropane (I) and diethyl amine (II) yields 1-diethylamino-2-propanol (III). 2-Heptyloxyaniline (IV) is reacted with a solution of phosgene in toluene to give 2-heptyloxyphenyliso cyanate (V), which is treated with the aminoalcohol (III) to give title compound.

参考文献No.556266
标题:Studies on local anesthetics. LXV. Basic esters of o-alkoxycarbanilic acids with local-anesthetic and anti-arrhythmic effects
作者:Benes, L.; Svec, P.; Kozlovsky, J.; Borovansky, A.
来源:Cesk Farm 1978,27(4),167
合成路线图解说明:

Reaction of 1,2-epoxypropane (I) and diethyl amine (II) yields 1-diethylamino-2-propanol (III). 2-Heptyloxyaniline (IV) is reacted with a solution of phosgene in toluene to give 2-heptyloxyphenyliso cyanate (V), which is treated with the aminoalcohol (III) to give title compound.

参考文献No.700065
标题:Basic isopropyl esters of alkoxy-subsituted carbanilics acids. Local anesthetics. XLIII
作者:Hartl, J.; Benes, L.; Kopacova, L.; Borovansky, A.
来源:Acta Fac Pharm Univ Comeniana 1973,23(2),81
合成路线图解说明:

Reaction of 1,2-epoxypropane (I) and diethyl amine (II) yields 1-diethylamino-2-propanol (III). 2-Heptyloxyaniline (IV) is reacted with a solution of phosgene in toluene to give 2-heptyloxyphenyliso cyanate (V), which is treated with the aminoalcohol (III) to give title compound.

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