【药物名称】Norfloxacin succinil, Eminor
化学结构式(Chemical Structure):
参考文献No.2722
标题:Cpds. having antibacterial activity, process for their preparation and pharmaceutical compsns. Containing them
作者:Di Schiena, M. (Farmades)
来源:EP 0155006
合成路线图解说明:

By acylation of 1-ethyl-6-fluoro-4-oxo-7-piperazine-1,4-dihydroquinoline-3-carboxylic acid (I) with succinic anhydride (II) in refluxing dichloromethane. Acetic acid can also be used as solvent in the acylation.

参考文献No.113259
标题:NORFLOXACIN SUCCINIL
作者:Prous, J.; Casta馿r, J.
来源:Drugs Fut 1990,15(6),578
合成路线图解说明:

By acylation of 1-ethyl-6-fluoro-4-oxo-7-piperazine-1,4-dihydroquinoline-3-carboxylic acid (I) with succinic anhydride (II) in refluxing dichloromethane. Acetic acid can also be used as solvent in the acylation.

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