【药物名称】Suramin sodium, NF-060, CI-1003, NSC-34936, Germanin, Moranyl, Antrypol, Metaret
化学结构式(Chemical Structure):
参考文献No.53729
标题:Suramin Sodium
作者:Casta馿r, J.; Serradell, M.N.
来源:Drugs Fut 1986,11(10),860
合成路线图解说明:

Several procedures for obtaining titte compound have been reported: In one method the acylation of 1 naphthylamine 4,6,8-trisulfonic acid trisodium salt (I) with 4 methyl-3-nitrobenzoyt chloride (II) yields the correspond ing amide (III), which is reduced with Fe in acetic acid to the amine (IV). Acylation of (IV) with 3-nitrobenzoyl chloride (V) affords the nitro diamide (VI), which is reduced with Fe and acetic acid before to the amine (VII). Finally, this compound is condensed with phosgene.

参考文献No.700229
标题:
作者:Fourneau; et al.
来源:Compt Rend Acad Sci 1924,178675
合成路线图解说明:

Several procedures for obtaining titte compound have been reported: In one method the acylation of 1 naphthylamine 4,6,8-trisulfonic acid trisodium salt (I) with 4 methyl-3-nitrobenzoyt chloride (II) yields the correspond ing amide (III), which is reduced with Fe in acetic acid to the amine (IV). Acylation of (IV) with 3-nitrobenzoyl chloride (V) affords the nitro diamide (VI), which is reduced with Fe and acetic acid before to the amine (VII). Finally, this compound is condensed with phosgene.

参考文献No.700243
标题:The manufacture of a symmetrical urea of m-aminobenzoyl-m-aminomethylbenzoyl-1-napthylamino-4,6,8-trisulphonate of sodium
作者:Freres, P.; Foruneau, E.; Trefouel, J.
来源:GB 224849
合成路线图解说明:

Several procedures for obtaining titte compound have been reported: In one method the acylation of 1 naphthylamine 4,6,8-trisulfonic acid trisodium salt (I) with 4 methyl-3-nitrobenzoyt chloride (II) yields the correspond ing amide (III), which is reduced with Fe in acetic acid to the amine (IV). Acylation of (IV) with 3-nitrobenzoyl chloride (V) affords the nitro diamide (VI), which is reduced with Fe and acetic acid before to the amine (VII). Finally, this compound is condensed with phosgene.

参考文献No.700248
标题:
作者:Heymann
来源:Angew Chem 1924,37585
合成路线图解说明:

Several procedures for obtaining titte compound have been reported: In one method the acylation of 1 naphthylamine 4,6,8-trisulfonic acid trisodium salt (I) with 4 methyl-3-nitrobenzoyt chloride (II) yields the correspond ing amide (III), which is reduced with Fe in acetic acid to the amine (IV). Acylation of (IV) with 3-nitrobenzoyl chloride (V) affords the nitro diamide (VI), which is reduced with Fe and acetic acid before to the amine (VII). Finally, this compound is condensed with phosgene.

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