【药物名称】Cefotiam cilexetil, Cefotiam hexetil, SCE-2174, Pansporin T
化学结构式(Chemical Structure):
参考文献No.3359
标题:Antibacterial solid compsn. for oral administratio
作者:Hirai, S.; Koyama, H.; Makino, T. (Takeda Chemical Industries, Ltd.)
来源:EP 0163433; JP 1985233012; JP 1987030713
合成路线图解说明:

The reaction of 1-chloroethyl chloroformate (I) with cyclohexanol (II) by means of pyridine in dichloromethane gives 1-chloroethyl cyclohexyl carbonate (III), which is converted to the corresponding iodoethyl derivative (IV) with NaI in hot acetonitrile. Finaly this compound is condensed with potassium 7beta-[2-(2-aminothiazol-4-yl)acetamido]-3-[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylate (V) in DMF.

参考文献No.62407
标题:SCE-2174
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1988,13(3),231
合成路线图解说明:

The reaction of 1-chloroethyl chloroformate (I) with cyclohexanol (II) by means of pyridine in dichloromethane gives 1-chloroethyl cyclohexyl carbonate (III), which is converted to the corresponding iodoethyl derivative (IV) with NaI in hot acetonitrile. Finaly this compound is condensed with potassium 7beta-[2-(2-aminothiazol-4-yl)acetamido]-3-[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylate (V) in DMF.

参考文献No.547087
标题:Orally active 1-(cyclohexyloxycarbonyloxy)alkyl es
作者:Nishimura, T.; Yoshimura, Y.; Miyake, A.; Yamaoka, M.; Takanohashi, K.; Hamaguchi, N.; Hirai, S.; Yashiki, T.; Numata, M.
来源:J Antibiot 1987,40(1),81
合成路线图解说明:

The reaction of 1-chloroethyl chloroformate (I) with cyclohexanol (II) by means of pyridine in dichloromethane gives 1-chloroethyl cyclohexyl carbonate (III), which is converted to the corresponding iodoethyl derivative (IV) with NaI in hot acetonitrile. Finaly this compound is condensed with potassium 7beta-[2-(2-aminothiazol-4-yl)acetamido]-3-[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylate (V) in DMF.

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