【药物名称】Pyrextramine
化学结构式(Chemical Structure):
参考文献No.53619
标题:Pyrextramine
作者:Brasili, L.
来源:Drugs Fut 1986,11(1),32
合成路线图解说明:

N1,N1'-Dithiobis(ethane-2,1-diyl)bis(hexane-1,6-diamine) (II) is prepared starting from 6-aminohexylcyste amine (I) by potassium ferricyanide oxidation. The condensation of (II) with pyrrol 2-carboxaldehyde and subsequent reduction with NaHB4 of the resulting Schitf base gives (III), which is crvstallized as tetraoxatate.

参考文献No.555887
标题:Structure-activity relationships among benextramine-related tetraamine disulfides at peripheral alpha-adrenoreceptors
作者:Angeli, P.; Brasili, L.; Brancia, E.; Giardina,.D.; Quaglia, W.; Melchiorre, C.
来源:J Med Chem 1985,28(11),1643
合成路线图解说明:

N1,N1'-Dithiobis(ethane-2,1-diyl)bis(hexane-1,6-diamine) (II) is prepared starting from 6-aminohexylcyste amine (I) by potassium ferricyanide oxidation. The condensation of (II) with pyrrol 2-carboxaldehyde and subsequent reduction with NaHB4 of the resulting Schitf base gives (III), which is crvstallized as tetraoxatate.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us