【药物名称】Buspirone hydrochloride, APC-6003(oral), APC-6002(topical), MJ-9022-1, Buspimen, Bespar, Narol, BuSpar
化学结构式(Chemical Structure):
参考文献No.53529
标题:Buspirone
作者:Casta馿r, J.; Thorpe, P.
来源:Drugs Fut 1976,1(9),409
合成路线图解说明:

The condensation of 1-(2-pyrimidinyl)piperazine (I) with 3-chloro-1-cyanopropane (II) by means of Na2CO3 in n-butanol gives 4-(2-pyrimidinyl)-1-(3-cyanopropyl)piperazine (III). This product is reduced with LiAlH4 or with H2 and Raney-Ni yielding 4-(2-pyrimidinyl)-1-(4-aminobutyl)piperazine (IV), which is finally condensed with 8-oxaspiro[4.5]decane-7,9-dione-(3,3-tetramethylene-glutaric anhydride) (V) in pyridine.

参考文献No.607580
标题:Psychosedative agents. 2. 8-(4-substituted-1-piperazinylalkyl)-8-azaspiro-[4,5]decane-7,9-diones
作者:Allen, L.E.; Ferguson, H.C.; Kissel, J.W.
来源:J Med Chem 1972,15(5),477-479
合成路线图解说明:

The condensation of 1-(2-pyrimidinyl)piperazine (I) with 3-chloro-1-cyanopropane (II) by means of Na2CO3 in n-butanol gives 4-(2-pyrimidinyl)-1-(3-cyanopropyl)piperazine (III). This product is reduced with LiAlH4 or with H2 and Raney-Ni yielding 4-(2-pyrimidinyl)-1-(4-aminobutyl)piperazine (IV), which is finally condensed with 8-oxaspiro[4.5]decane-7,9-dione-(3,3-tetramethylene-glutaric anhydride) (V) in pyridine.

参考文献No.701134
标题:N-(Heteroarcyclic)piperazizylalkylazaspiroalkanediones
作者:Wu, Y.H.; et al.
来源:DE 2057845; FR 2073406; GB 1332194; US 3717634
合成路线图解说明:

The condensation of 1-(2-pyrimidinyl)piperazine (I) with 3-chloro-1-cyanopropane (II) by means of Na2CO3 in n-butanol gives 4-(2-pyrimidinyl)-1-(3-cyanopropyl)piperazine (III). This product is reduced with LiAlH4 or with H2 and Raney-Ni yielding 4-(2-pyrimidinyl)-1-(4-aminobutyl)piperazine (IV), which is finally condensed with 8-oxaspiro[4.5]decane-7,9-dione-(3,3-tetramethylene-glutaric anhydride) (V) in pyridine.

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