Cloranolol hydrochloride, GYKI-41099, Tobanum-药物合成数据库

【药物名称】Cloranolol hydrochloride, GYKI-41099, Tobanum

化学结构式(Chemical Structure):

参考文献No.	53500
标题:	GYKI-41099
作者:	Casta馿r, J.; Sumgurbey, K.
来源:	Drugs Fut 1978,3(4),295

合成路线图解说明: Compound can be prepared in three different ways: 1) Condensation of 2,5-dichlorophenol (I) with epichlorohydrin (A) by means of NaOH in water to give 1-(2,5-dichlorophenoxy)-2,3-epoxypropane (II), which is then condensed again with tert-butylamine in refluxing ethanol. Finally, HCl in ethanol is added. 2) Condensation of (I) with epichlorohydrin (A) by means of pyridine gives 1-(2,5-dichlorophenoxy)-3-chloro-2-propanol (III), which is then condensed with tert-butylamine as before. 3) Condensation of (I) with 1-(tertbutylamino)-2,3-epoxypropane (B) or with 1-(tertbutylamino)-3-chloro-2-propanol (C) by means of NaOH in refluxing ethanol.

参考文献No.	701011
标题:	Aminopropanol derivative
作者:	Hajos, A.; et al.
来源:	DE 2213044; FR 2130284; GB 1337921; NL 7203323

合成路线图解说明: Compound can be prepared in three different ways: 1) Condensation of 2,5-dichlorophenol (I) with epichlorohydrin (A) by means of NaOH in water to give 1-(2,5-dichlorophenoxy)-2,3-epoxypropane (II), which is then condensed again with tert-butylamine in refluxing ethanol. Finally, HCl in ethanol is added. 2) Condensation of (I) with epichlorohydrin (A) by means of pyridine gives 1-(2,5-dichlorophenoxy)-3-chloro-2-propanol (III), which is then condensed with tert-butylamine as before. 3) Condensation of (I) with 1-(tertbutylamino)-2,3-epoxypropane (B) or with 1-(tertbutylamino)-3-chloro-2-propanol (C) by means of NaOH in refluxing ethanol.