【药物名称】Terazosin hydrochloride, MY-208, A-45975, ABT-975, Abbott-45975, Hytrin, Hytrine, Flotrin, Zayasel, Magnurol, Heitrin, Urodie, Hytracin, Vasomet, Hytrin BPH, Vasocard
化学结构式(Chemical Structure):
参考文献No.46496
标题:Antihypertensive agents
作者:Winn, M.; Kyncl, J.; Dunnigan, D.A.; Jones, P.H. (Abbott Laboratories Inc.)
来源:CA 1057754; CH 602712; DE 2646186; FR 2327787; GB 1517403; JP 52048678; US 4026894; US 4112097
合成路线图解说明:

The reaction of furoyl chloride (I) with piperazine (II) by means of NaOH in water gives N-(2-furoyl)piperazin (III), which is reduced with H2 over Raney-Ni in methanol to afford N-(tetrahydro-2-furoyl)piperazine (IV) . Finally, this compound is condensed with 2-chloro-4-amino-6,7-dimethoxyquinazoline (V) in refluxing methoxyethanol.

参考文献No.46497
标题:1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
作者:Roteman, R. (Abbott Laboratories Inc.)
来源:CA 1081229; DE 2831112; FR 2399430; JP 54027588
合成路线图解说明:

The reaction of furoyl chloride (I) with piperazine (II) by means of NaOH in water gives N-(2-furoyl)piperazin (III), which is reduced with H2 over Raney-Ni in methanol to afford N-(tetrahydro-2-furoyl)piperazine (IV) . Finally, this compound is condensed with 2-chloro-4-amino-6,7-dimethoxyquinazoline (V) in refluxing methoxyethanol.

参考文献No.53462
标题:Terazosin Hydrochloride
作者:Thorpe, P.; Casta馿r, J.; Serradell, M.N.; Blancafort, P.
来源:Drugs Fut 1983,8(1),45
合成路线图解说明:

The reaction of furoyl chloride (I) with piperazine (II) by means of NaOH in water gives N-(2-furoyl)piperazin (III), which is reduced with H2 over Raney-Ni in methanol to afford N-(tetrahydro-2-furoyl)piperazine (IV) . Finally, this compound is condensed with 2-chloro-4-amino-6,7-dimethoxyquinazoline (V) in refluxing methoxyethanol.

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