【药物名称】Nitrendipine, Bay-e-5009, Baylotensin, Baypress, Bayotensin
化学结构式(Chemical Structure):
参考文献No.46554
标题:Verfahren zur Herstellung con neuen unsymmetrischen 1,4-Dihydropyridindicarbos鋟reestern
作者:Meyer, H.; Bossert, F. (Bayer AG)
来源:CA 934758; CH 571492; DD 104520; DE 2117573; NL 7204695
合成路线图解说明:

2) This compound can also be obtained by direct cyclization of ethyl acetoacetate (I) with 3-nitrobenzaldehyde (II) and 3-aminocrotonate (IV) in refluxing ethanol.

参考文献No.53404
标题:Nitrendipine
作者:Serradell, M.N.; Casta馿r, J.; Grau, M.; Blancafort, P.
来源:Drugs Fut 1983,8(6),508
合成路线图解说明:

1) The condensation of ethyl acetoacetate (I) with 3-nitrobenzaldehyde (II) in toluene gives ethyl 2-(3-nitrobenzylidene)acetoacetate (III), which is then cyclized with methyl 3-aminocrotonate (IV) [prepared from methyl acetoacetate (V) with NH3 and p-toluenesulfonic acid]; the reaction is carried out in refluxing ethanol.

合成路线图解说明:

2) This compound can also be obtained by direct cyclization of ethyl acetoacetate (I) with 3-nitrobenzaldehyde (II) and 3-aminocrotonate (IV) in refluxing ethanol.

参考文献No.604478
标题:Synthesis and comparative pharmacological studies of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylates with non-identical estes function
作者:Wehinger, E.; Stoepel, K.; Vater, W.; Meyer, H.; Bossert, F.
来源:Arzneim-Forsch Drug Res 1981,31(3),407-409
合成路线图解说明:

1) The condensation of ethyl acetoacetate (I) with 3-nitrobenzaldehyde (II) in toluene gives ethyl 2-(3-nitrobenzylidene)acetoacetate (III), which is then cyclized with methyl 3-aminocrotonate (IV) [prepared from methyl acetoacetate (V) with NH3 and p-toluenesulfonic acid]; the reaction is carried out in refluxing ethanol.

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