【药物名称】Cistinexine, Rec-15-1884
化学结构式(Chemical Structure):
参考文献No.3305
标题:Therapeutically effective derivatives of cystine
作者:Nardi, D.; Tajana, A.; Motta, G.; Cazzulani, P.; Graziani, G. (Recordati Industria Chimica e Farmaceutica SpA)
来源:DE 3225274; EP 0069527; FR 2509298; GB 2102792; JP 58032860; US 4438133
合成路线图解说明:

The reaction of cysteine (I) with benzyl chloroformate (II) in the usual way gives the corresponding di(benzyloxycarbonyl) derivative (III), which is treated with PCl5 or SOCl2 in CHCl3 to afford the bisacyl chloride (IV). Finally, this compound is condensed with 4,6-dibromo-2-(cyclohexylmethylaminomethyl) aniline (V) in ethyl acetate.

参考文献No.53392
标题:Cistinexine
作者:Casta馿r, J.; Serradell, M.N.
来源:Drugs Fut 1986,11(3),181
合成路线图解说明:

The reaction of cysteine (I) with benzyl chloroformate (II) in the usual way gives the corresponding di(benzyloxycarbonyl) derivative (III), which is treated with PCl5 or SOCl2 in CHCl3 to afford the bisacyl chloride (IV). Finally, this compound is condensed with 4,6-dibromo-2-(cyclohexylmethylaminomethyl) aniline (V) in ethyl acetate.

参考文献No.700471
标题:
作者:Giannini, E.H.
来源:Farm Sci Ed 1985,40(2),108-119
合成路线图解说明:

The reaction of cysteine (I) with benzyl chloroformate (II) in the usual way gives the corresponding di(benzyloxycarbonyl) derivative (III), which is treated with PCl5 or SOCl2 in CHCl3 to afford the bisacyl chloride (IV). Finally, this compound is condensed with 4,6-dibromo-2-(cyclohexylmethylaminomethyl) aniline (V) in ethyl acetate.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us