【药物名称】Zaltidine, CP-57361
化学结构式(Chemical Structure):
参考文献No.3284
标题:2-Guanidino-4-(2-methyl-4-imidazlyl)thiazoles in the treatment of rheumatoid arthritis
作者:Larson, D.L. (Pfizer Inc.)
来源:EP 0178822; JP 1986091122; US 4591595
合成路线图解说明:

The bromination of 4-acetyl-2-methylimidazole (I) with Br2 in 48% HBr at 70 C gives 4-bromoacetyl-2-methylimidazole (II), which is then cyclized with amidinothiourea (III) in refluxing acetone.

参考文献No.53362
标题:Zaltidine
作者:Casta馿r, J.; Serradell, M.N.; Casta馿r, R.M.
来源:Drugs Fut 1987,12(7),640
合成路线图解说明:

The bromination of 4-acetyl-2-methylimidazole (I) with Br2 in 48% HBr at 70 C gives 4-bromoacetyl-2-methylimidazole (II), which is then cyclized with amidinothiourea (III) in refluxing acetone.

参考文献No.607775
标题:Bioisosteric prototype design of biaryl imidazlyl and triazolyl competitive histamine H2-receptor antagonists
作者:Lipinski, C.A.; LaMattina, J.L.; Oates, P.J.
来源:J Med Chem 1986,29(11),2154-2163
合成路线图解说明:

The bromination of 4-acetyl-2-methylimidazole (I) with Br2 in 48% HBr at 70 C gives 4-bromoacetyl-2-methylimidazole (II), which is then cyclized with amidinothiourea (III) in refluxing acetone.

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