Indomethacin butanediol ester, SY-6001-药物合成数据库

【药物名称】Indomethacin butanediol ester, SY-6001

化学结构式(Chemical Structure):

参考文献No.	3083
标题:	Esters of indomethacin
作者:	Isomae, K.; Kuwamura, T.; Mogi, K.; Ogawa, Y.; Sato, S. (SSP Co., Ltd.)
来源:	DE 3235850; GB 2125786

合成路线图解说明: The reaction of indomethacin (I) with SOCl2 in hot benzene gives the corresponding acyl chloride (II), which is then condensed with 2,3-butanediol (III) by means of pyridine in THF.

参考文献No.	53115
标题:	SY-6001
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1986,11(3),194

合成路线图解说明: The reaction of indomethacin (I) with SOCl2 in hot benzene gives the corresponding acyl chloride (II), which is then condensed with 2,3-butanediol (III) by means of pyridine in THF.