Vinmegallate, RGH-4417-药物合成数据库

【药物名称】Vinmegallate, RGH-4417

化学结构式(Chemical Structure):

参考文献No.	42006
标题:	Polycyclic compounds containing a double bond in the D-ring pharmaceutical compositions containing them and methods of treating psoriasis with them
作者:	Keve, T.; et al. (Gedeon Richter Ltd.)
来源:	DE 3204630; FR 2499572; GB 2094297; GB 2125788; HU 183323; JP 57181087; US 4424223

合成路线图解说明: Tabersonine (I), isolated from plant material, reacted with disuccinoyl peroxide in methanol - HCl - water gives the rearranged product (II). Dehydration of (II) with formic acid and acetyl chloride in CH2Cl2 yields the ester (III), which is reduced with LiAlH4 to the alcohol (IV). Finally, acylation with 3,4,5 trimethoxybenzoyl chloride (V) results in RGH-4417 (VI).

参考文献No.	53069
标题:	RGH-4417
作者:	Bal醶s, M.Z.; N骻r醖i, M.; Kiss, B.
来源:	Drugs Fut 1986,11(8),663

合成路线图解说明: Tabersonine (I), isolated from plant material, reacted with disuccinoyl peroxide in methanol - HCl - water gives the rearranged product (II). Dehydration of (II) with formic acid and acetyl chloride in CH2Cl2 yields the ester (III), which is reduced with LiAlH4 to the alcohol (IV). Finally, acylation with 3,4,5 trimethoxybenzoyl chloride (V) results in RGH-4417 (VI).