【药物名称】Avarone
化学结构式(Chemical Structure):
参考文献No.51940
标题:Avarone and Avarol
作者:M黮ler, W.E.G.; Zahn, R.K.; Maidhof, A.; Gasic, M.J.; Schr鰀er, H.C.; Eich, E.
来源:Drugs Fut 1985,10(11),887
合成路线图解说明:

Avarol (I) has been isolated from the marine sponge Dysidea avara, which is ubiquitous near the Atlantic coast of Europe. in the Mediterranean and around the Maldive Islands. The ground material is extracted with ethyl acetate. The organic phase is dried over Mg2SO4 and then evaporated to dryness yielding a tar-like residue. This material is taken up in benzene and purified by silica gel column chromatography using benzene/10% ethyl acetate as solvent. The avarol fractions are concentrated; purified avaro is obtained after several crystallizations from acetone-methylene chloride, with yield of 2.7 g avarol from 1kg of fresh material. Avarone is obtained from its corresponding hydroquinone avarol (I) by Ag2O oxidation.

参考文献No.604651
标题:Avarol, a cytostatically active compound from the marine sponge Dysidea avara
作者:Zahn, R.K.; Dogovic, N.; Eich, E.; Gasic, M.J.; Diehl-Seifert, B.; Maidhof, A.; Becker, C.; M黮ler, W.E.G.
来源:Comp Biochem Physiol (C) 1985,80(1),47-52
合成路线图解说明:

Avarol (I) has been isolated from the marine sponge Dysidea avara, which is ubiquitous near the Atlantic coast of Europe. in the Mediterranean and around the Maldive Islands. The ground material is extracted with ethyl acetate. The organic phase is dried over Mg2SO4 and then evaporated to dryness yielding a tar-like residue. This material is taken up in benzene and purified by silica gel column chromatography using benzene/10% ethyl acetate as solvent. The avarol fractions are concentrated; purified avaro is obtained after several crystallizations from acetone-methylene chloride, with yield of 2.7 g avarol from 1kg of fresh material. Avarone is obtained from its corresponding hydroquinone avarol (I) by Ag2O oxidation.

参考文献No.700629
标题:Potent antileukemic activity of the novel cytostatic agent avarone and its analogues in vitro and in vivo
作者:Maidhof, A.; Schr鰀er, H.C.; Kurelec, B.; Seibert, G.; Gasic, M.J.; Eich, E.; Bernd, A.; Heidemann, D.; M黮ler, W.E.G.; Zahn, R.K.
来源:Cancer Res 1985,45(10),4822
合成路线图解说明:

Avarol (I) has been isolated from the marine sponge Dysidea avara, which is ubiquitous near the Atlantic coast of Europe. in the Mediterranean and around the Maldive Islands. The ground material is extracted with ethyl acetate. The organic phase is dried over Mg2SO4 and then evaporated to dryness yielding a tar-like residue. This material is taken up in benzene and purified by silica gel column chromatography using benzene/10% ethyl acetate as solvent. The avarol fractions are concentrated; purified avaro is obtained after several crystallizations from acetone-methylene chloride, with yield of 2.7 g avarol from 1kg of fresh material. Avarone is obtained from its corresponding hydroquinone avarol (I) by Ag2O oxidation.

参考文献No.800044
标题:Avarol, a novel sesquiterpenoid hydroquinone with a rearranged drimane skeleton from the sponge Dysidea avara
作者:Minale, L.; Riccio, R.; Sodano, G.
来源:Tetrahedron Lett 1974,363401
合成路线图解说明:

Avarol (I) has been isolated from the marine sponge Dysidea avara, which is ubiquitous near the Atlantic coast of Europe. in the Mediterranean and around the Maldive Islands. The ground material is extracted with ethyl acetate. The organic phase is dried over Mg2SO4 and then evaporated to dryness yielding a tar-like residue. This material is taken up in benzene and purified by silica gel column chromatography using benzene/10% ethyl acetate as solvent. The avarol fractions are concentrated; purified avaro is obtained after several crystallizations from acetone-methylene chloride, with yield of 2.7 g avarol from 1kg of fresh material. Avarone is obtained from its corresponding hydroquinone avarol (I) by Ag2O oxidation.

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