Fosfomycin tromethamine, Fosfomycin trometamol, Z-1282, Monurol, Monuril-药物合成数据库

【药物名称】Fosfomycin tromethamine, Fosfomycin trometamol, Z-1282, Monurol, Monuril

化学结构式(Chemical Structure):

参考文献No.	2830
标题:	Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol-(2R-cis)-3-methyloxiranyl)phosphonate, its preparation and pharmaceutical compositions containing it
作者:	Chiarino, D.; Della Bella, D.; Ferrari, V. (Zambon Group SpA)
来源:	BE 885756; DE 3061359; EP 0027597; FR 2467856; JP 8177290; US 4863908

合成路线图解说明: By treatment of bis(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R-cis)(3-methyl-2-oxyranyl)phosphonate (I) with p-toluenesulfonic acid in hot ethanol.

参考文献No.	52793
标题:	Fosfomycin Trometamol
作者:	Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1986,11(1),16

合成路线图解说明: By treatment of bis(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R-cis)(3-methyl-2-oxyranyl)phosphonate (I) with p-toluenesulfonic acid in hot ethanol.