By condensation of 3-(acetoxymethyl)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino) acetamido]-3-cephem-4-carboxylate sodium salt (I) with 4-(5-oxazolyl)pyridine by means of NaI and HCl in hot acetonitrile. The title product has been obtained in high purity by passing its NaOH solution, adjusted at pH 6.8, through a column packed with Diaion PA 406. The eluate is concentrated and acidified at pH 1.5 with H2SO4. After cooling, the H2SO4 salt of the title product is obtained with a 99.8% purity. Another purification method is to pass the NaOH solution through a Cl-form Diaion PA 406 column. The eluate is then subjected to reverse osmosis on a RS-9267 membrane to eliminate the NaCl (final purity 99.2%). The synthesis of 7-amino-3-[4-(oxazol-5-yl)-1-pyridinio]methyl-3-cephem-4-carboxylate borofluorate as an intermediate in the synthesis of title compound has been reported. The enzyme pancreatine has been used to protect and deprotect the 7-amino group of cephalosporin.

By condensation of 3-(acetoxymethyl)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino) acetamido]-3-cephem-4-carboxylate sodium salt (I) with 4-(5-oxazolyl)pyridine by means of NaI and HCl in hot acetonitrile. The title product has been obtained in high purity by passing its NaOH solution, adjusted at pH 6.8, through a column packed with Diaion PA 406. The eluate is concentrated and acidified at pH 1.5 with H2SO4. After cooling, the H2SO4 salt of the title product is obtained with a 99.8% purity. Another purification method is to pass the NaOH solution through a Cl-form Diaion PA 406 column. The eluate is then subjected to reverse osmosis on a RS-9267 membrane to eliminate the NaCl (final purity 99.2%). The synthesis of 7-amino-3-[4-(oxazol-5-yl)-1-pyridinio]methyl-3-cephem-4-carboxylate borofluorate as an intermediate in the synthesis of title compound has been reported. The enzyme pancreatine has been used to protect and deprotect the 7-amino group of cephalosporin.

By condensation of 3-(acetoxymethyl)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino) acetamido]-3-cephem-4-carboxylate sodium salt (I) with 4-(5-oxazolyl)pyridine by means of NaI and HCl in hot acetonitrile. The title product has been obtained in high purity by passing its NaOH solution, adjusted at pH 6.8, through a column packed with Diaion PA 406. The eluate is concentrated and acidified at pH 1.5 with H2SO4. After cooling, the H2SO4 salt of the title product is obtained with a 99.8% purity. Another purification method is to pass the NaOH solution through a Cl-form Diaion PA 406 column. The eluate is then subjected to reverse osmosis on a RS-9267 membrane to eliminate the NaCl (final purity 99.2%). The synthesis of 7-amino-3-[4-(oxazol-5-yl)-1-pyridinio]methyl-3-cephem-4-carboxylate borofluorate as an intermediate in the synthesis of title compound has been reported. The enzyme pancreatine has been used to protect and deprotect the 7-amino group of cephalosporin.

By condensation of 3-(acetoxymethyl)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino) acetamido]-3-cephem-4-carboxylate sodium salt (I) with 4-(5-oxazolyl)pyridine by means of NaI and HCl in hot acetonitrile. The title product has been obtained in high purity by passing its NaOH solution, adjusted at pH 6.8, through a column packed with Diaion PA 406. The eluate is concentrated and acidified at pH 1.5 with H2SO4. After cooling, the H2SO4 salt of the title product is obtained with a 99.8% purity. Another purification method is to pass the NaOH solution through a Cl-form Diaion PA 406 column. The eluate is then subjected to reverse osmosis on a RS-9267 membrane to eliminate the NaCl (final purity 99.2%). The synthesis of 7-amino-3-[4-(oxazol-5-yl)-1-pyridinio]methyl-3-cephem-4-carboxylate borofluorate as an intermediate in the synthesis of title compound has been reported. The enzyme pancreatine has been used to protect and deprotect the 7-amino group of cephalosporin.

By condensation of 3-(acetoxymethyl)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino) acetamido]-3-cephem-4-carboxylate sodium salt (I) with 4-(5-oxazolyl)pyridine by means of NaI and HCl in hot acetonitrile. The title product has been obtained in high purity by passing its NaOH solution, adjusted at pH 6.8, through a column packed with Diaion PA 406. The eluate is concentrated and acidified at pH 1.5 with H2SO4. After cooling, the H2SO4 salt of the title product is obtained with a 99.8% purity. Another purification method is to pass the NaOH solution through a Cl-form Diaion PA 406 column. The eluate is then subjected to reverse osmosis on a RS-9267 membrane to eliminate the NaCl (final purity 99.2%). The synthesis of 7-amino-3-[4-(oxazol-5-yl)-1-pyridinio]methyl-3-cephem-4-carboxylate borofluorate as an intermediate in the synthesis of title compound has been reported. The enzyme pancreatine has been used to protect and deprotect the 7-amino group of cephalosporin.

By condensation of 3-(acetoxymethyl)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino) acetamido]-3-cephem-4-carboxylate sodium salt (I) with 4-(5-oxazolyl)pyridine by means of NaI and HCl in hot acetonitrile. The title product has been obtained in high purity by passing its NaOH solution, adjusted at pH 6.8, through a column packed with Diaion PA 406. The eluate is concentrated and acidified at pH 1.5 with H2SO4. After cooling, the H2SO4 salt of the title product is obtained with a 99.8% purity. Another purification method is to pass the NaOH solution through a Cl-form Diaion PA 406 column. The eluate is then subjected to reverse osmosis on a RS-9267 membrane to eliminate the NaCl (final purity 99.2%). The synthesis of 7-amino-3-[4-(oxazol-5-yl)-1-pyridinio]methyl-3-cephem-4-carboxylate borofluorate as an intermediate in the synthesis of title compound has been reported. The enzyme pancreatine has been used to protect and deprotect the 7-amino group of cephalosporin.