Tropisetron, ICS-205930, Novaban, Navoban-药物合成数据库

【药物名称】Tropisetron, ICS-205930, Novaban, Navoban

化学结构式(Chemical Structure):

参考文献No.	2694
标题:	Pharmaceutically useful heterocyclic and carbocyclic acid esters and amides of alkylene bridged piperidines
作者:	Donatsch, P.; Engel, G.; Stadler, P.; Richardson, B.P.; H黦i, B. (Novartis AG; Novartis Deutschland GmbH)
来源:	CH 669792; CH 669954; DE 3322574; GB 2166726; GB 2166727; GB 2166728; US 4789673

合成路线图解说明: By condensation of indole 3-carbonyl chloride (I) with endo-8-methyl-8-azabicyclo[3.2.1]octan-3-ol (II) by means of butyllithium in THF, or Na2CO3 in the same solvent.

参考文献No.	52625
标题:	ICS-205930
作者:	Casta馿r, J.; Serradell, M.N.
来源:	Drugs Fut 1986,11(2),106

合成路线图解说明: By condensation of indole 3-carbonyl chloride (I) with endo-8-methyl-8-azabicyclo[3.2.1]octan-3-ol (II) by means of butyllithium in THF, or Na2CO3 in the same solvent.