【药物名称】Ormaplatin, Tetraplatin, U-77233, NSC-276017(diastereomeric mixture), NSC-363812
化学结构式(Chemical Structure):
参考文献No.123499
标题:Synthesis of [195mPt]-tetraplatin
作者:Wyrick, S.D.; Chaney, S.G.
来源:J Label Compd Radiopharm 1990,28(7),753
合成路线图解说明:

A new synthesis of [195mPt]-tetraplatin has been described: By reaction of potassium hexachloroplatinate (195Pt) with trans-1,2-cyclohexanediamine in water.

参考文献No.537104
标题:Synthesis, physical properties, and antitumor activity of tetraplatin and related tetrachloroplatinum(IV) stereoisomers of 1,2-diaminocyclohexane
作者:Anderson, W.K.; Quagliato, D.A.; Haugwitz, R.D.; Narayanan, V.L.; Wolpert-DeFilippes, M.K.
来源:Cancer Treat Rep 1986,70(8),997-1002
合成路线图解说明:

Potassium tetrachloroplatinate (I) is treated with an equivalent amount of 1,2-diaminocyclohexane in degassed water under nitrogen. The precipitated complex (II) is filtered and washed with HCl, ethanol and diethyl ether. The precipitate is dissolved in N,N-dimethylformamide, filtered and reprecipitated by addition of methanol. The precipitate is collected and suspended in 0.5N HCl and treated with chlorine gas at 100 C to convert to the tetrachloroplatinum(IV) complex. Removal of excess chlorine and then solvent, dissolution in methanol, filtration and removal of the methanol by vacuum yields the yellow product (III) in about 83% yield.

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