【药物名称】Tioxamast, F-1865
化学结构式(Chemical Structure):
参考文献No.13478
标题:4-Phenyl-2-thiazolyloxamate derivs., method for their preparation and their application in the treatment of asthma
作者:Casadio, S.; Cousse, H.; Tarayre, J.P.; Mouzin, G. (Pierre Fabre S.A.)
来源:EP 0006368; ES 481633; FR 2429210; JP 55002684; US 4246271
合成路线图解说明:

The cyclization of p-methoxyacetophenone (I) with thiourea (II) by means of SO2Cl2 gives 4-(p-methoxyphenyl)-2-aminothiazole (III), which is then reacted with ethoxalyl chloride (IV) in presence of a base to afford F-1865.

参考文献No.127621
标题:TIOXAMAST
作者:Tarayre, J.P.; Bonnaud, B.
来源:Drugs Fut 1990,15(5),469
合成路线图解说明:

The cyclization of p-methoxyacetophenone (I) with thiourea (II) by means of SO2Cl2 gives 4-(p-methoxyphenyl)-2-aminothiazole (III), which is then reacted with ethoxalyl chloride (IV) in presence of a base to afford F-1865.

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