Tesmilifene hydrochloride, BMY-33419, BMS-217380, DPPE, N,N-DPPE-药物合成数据库

【药物名称】Tesmilifene hydrochloride, BMY-33419, BMS-217380, DPPE, N,N-DPPE

化学结构式(Chemical Structure):

参考文献No.	2452
标题:	Novel cytotoxic aminoalkyl phenol ethers
作者:	Hermonat, M.W.; Brandes, L.J. (University of Manitoba)
来源:	EP 0153160; JP 1985190742; US 4803227

合成路线图解说明: The target product can be prepared by reacting para-benzylphenol (I) with 2-diethylaminoethylchloride hydrochloride (II) either by means of NaOH in H2O or with K2CO3 in DMF/acetone (at 60 C in both cases), followed by treatment with HCl to obtain the corresponding hydrochloride salt.

参考文献No.	619839
标题:	Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS)
作者:	Poirot, M.; De Medina, P.; Delarue, F.; Perie, J.-J.; Klaebe, A.; Faye, J.-C.
来源:	Bioorg Med Chem 2000,8(8),2007

合成路线图解说明: The target product can be prepared by reacting para-benzylphenol (I) with 2-diethylaminoethylchloride hydrochloride (II) either by means of NaOH in H2O or with K2CO3 in DMF/acetone (at 60 C in both cases), followed by treatment with HCl to obtain the corresponding hydrochloride salt.