【药物名称】CV-159
化学结构式(Chemical Structure):
参考文献No.2220
标题:Novel 1,4-dihydropyridine derivatives
作者:Masato, K.; Shinji, T.; Kozo, H.; Susumu, T. (Tokyo Tanabe Co., Ltd.)
来源:DE 3230400; FR 2511370; FR 8214008; GB 2108108; JP 88023193; US 4418197
合成路线图解说明:

Reaction of 6-chlorohexanol (I) with 3-phenyl-5-pyrazolone (II) in the presence of K2CO3 in DMF gives 6-(5-phenyl-3-pyrazolyloxy)hexyl alcohol (III), which affords the crystalline acetoacetate derivative (IV) by esterification of (III) with diketene in the presence of triethylamine. Reaction of (IV) and ammonium carbonate in refluxing methanol gives 3-aminocrotonic acid 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (V). This compound is finally cyclized with methyl 3-nitrobenzylidene acetoacetate (VI) in ethanol.

参考文献No.45890
标题:Powdery preparation of amorphous dihydropyridine compound
作者:Masato, K.; Shinji, T.; Tsutomu, A.; Setagaya, S.C.; Susumu, T. (Tokyo Tanabe Co., Ltd.)
来源:EP 0147171; JP 60139688
合成路线图解说明:

Reaction of 6-chlorohexanol (I) with 3-phenyl-5-pyrazolone (II) in the presence of K2CO3 in DMF gives 6-(5-phenyl-3-pyrazolyloxy)hexyl alcohol (III), which affords the crystalline acetoacetate derivative (IV) by esterification of (III) with diketene in the presence of triethylamine. Reaction of (IV) and ammonium carbonate in refluxing methanol gives 3-aminocrotonic acid 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (V). This compound is finally cyclized with methyl 3-nitrobenzylidene acetoacetate (VI) in ethanol.

参考文献No.85081
标题:CV-159
作者:Kamibayashi, M.
来源:Drugs Fut 1989,14(3),206
合成路线图解说明:

Reaction of 6-chlorohexanol (I) with 3-phenyl-5-pyrazolone (II) in the presence of K2CO3 in DMF gives 6-(5-phenyl-3-pyrazolyloxy)hexyl alcohol (III), which affords the crystalline acetoacetate derivative (IV) by esterification of (III) with diketene in the presence of triethylamine. Reaction of (IV) and ammonium carbonate in refluxing methanol gives 3-aminocrotonic acid 6-(5-phenyl-3-pyrazolyloxy)hexyl ester (V). This compound is finally cyclized with methyl 3-nitrobenzylidene acetoacetate (VI) in ethanol.

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