KT-362-药物合成数据库

【药物名称】KT-362

化学结构式(Chemical Structure):

参考文献No.	1784
标题:	Antihypertensive 1,5-benzothiazepine derivs. and compsns. thereof
作者:	Tomiyama, T. (Kotobuki Pharmaceutical Co., Ltd.)
来源:	US 4584292

合成路线图解说明: The acylation of 2,3,4,5-tetrahydrobenzo-1,5 thiazepine (I) with 3-bromopropionyl bromide (II) by means of pyridine in toluene gives 5-(3-bromo-propionyl)-2,3,4,5 tetrahydrobenzo-1,5-thiazepine (III), which is then condensed with 2-(3,4-dimethoxyphenyl)ethylamine (IV) in refluxing dichloromethane, and treated with fumaric acid.

参考文献No.	61993
标题:	KT-362
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1988,13(7),622

合成路线图解说明: The acylation of 2,3,4,5-tetrahydrobenzo-1,5 thiazepine (I) with 3-bromopropionyl bromide (II) by means of pyridine in toluene gives 5-(3-bromo-propionyl)-2,3,4,5 tetrahydrobenzo-1,5-thiazepine (III), which is then condensed with 2-(3,4-dimethoxyphenyl)ethylamine (IV) in refluxing dichloromethane, and treated with fumaric acid.