The condensation of 3-bromo-5-isoxazolylcarbonyl chloride (I) with diethyl malonate (II) gives the corresponding malonyl derivative (III), which is submitted to a decarboxylative hydrolysis yielding 5-acetyl-3-bromoisoxazole (IV). Bromination of (IV) affords 5-(bromoacetyl)-3-bromoisoxazole (V), which is reduced to 2-bromo-1-(3-bromo-5-isoxazolyl)ethanol (VI). Title compound is obtained by reaction of (VI) with tert-butylamine directly or via oxirane (VII), which is obtained by reaction of (VI) with sodium hydride, and finally by reaction of (VII) with tert-butylamine.

The condensation of 3-bromo-5-isoxazolylcarbonyl chloride (I) with diethyl malonate (II) gives the corresponding malonyl derivative (III), which is submitted to a decarboxylative hydrolysis yielding 5-acetyl-3-bromoisoxazole (IV). Bromination of (IV) affords 5-(bromoacetyl)-3-bromoisoxazole (V), which is reduced to 2-bromo-1-(3-bromo-5-isoxazolyl)ethanol (VI). Title compound is obtained by reaction of (VI) with tert-butylamine directly or via oxirane (VII), which is obtained by reaction of (VI) with sodium hydride, and finally by reaction of (VII) with tert-butylamine.

The condensation of 3-bromo-5-isoxazolylcarbonyl chloride (I) with diethyl malonate (II) gives the corresponding malonyl derivative (III), which is submitted to a decarboxylative hydrolysis yielding 5-acetyl-3-bromoisoxazole (IV). Bromination of (IV) affords 5-(bromoacetyl)-3-bromoisoxazole (V), which is reduced to 2-bromo-1-(3-bromo-5-isoxazolyl)ethanol (VI). Title compound is obtained by reaction of (VI) with tert-butylamine directly or via oxirane (VII), which is obtained by reaction of (VI) with sodium hydride, and finally by reaction of (VII) with tert-butylamine.