【药物名称】XC-386
化学结构式(Chemical Structure):
参考文献No.50476
标题:XC-386
作者:Teng, C.M.; Kuo, S.C.; Wang, J.P.
来源:Drugs Fut 1985,10(9),761
合成路线图解说明:

Hydrazine hydrate (I) is added dropwise under stirring to ethyl acetoacetate (II), which has been heated to 140 C, water and ethanol formed in the reaction are distilled off, and the mixture is heated at reflux. Upon completion of the reaction, the mixture is allowed to stand at room temperature, and the solid thus separated is collected and recrystallized from ethanol to obtain the title compound.

合成路线图解说明:

Suspension of 3-methyl-2-pyrazolin-5-one (I) is added dropwise under stirring to ethyl acetoacetate (II), which has been heated to 140 C, water and ethanol formed in the reaction are distilled off, and the mixture is heated at reflux. Upon completion of the reaction, the mixture is allowed to stand at room temperature, and the solid thus separated is collected and recrystallized from ethanol to obtain the title compound.

参考文献No.555595
标题:Studies on heterocyclic compounds. 6. Synthesis and analgesic and antiinflammatory activities of 3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives
作者:Kuo, S.C.; Huang, L.J.; Nakamura, H.
来源:J Med Chem 1984,27(4),539
合成路线图解说明:

Hydrazine hydrate (I) is added dropwise under stirring to ethyl acetoacetate (II), which has been heated to 140 C, water and ethanol formed in the reaction are distilled off, and the mixture is heated at reflux. Upon completion of the reaction, the mixture is allowed to stand at room temperature, and the solid thus separated is collected and recrystallized from ethanol to obtain the title compound.

合成路线图解说明:

Suspension of 3-methyl-2-pyrazolin-5-one (I) is added dropwise under stirring to ethyl acetoacetate (II), which has been heated to 140 C, water and ethanol formed in the reaction are distilled off, and the mixture is heated at reflux. Upon completion of the reaction, the mixture is allowed to stand at room temperature, and the solid thus separated is collected and recrystallized from ethanol to obtain the title compound.

参考文献No.700323
标题:
作者:
来源:J Taiwan Pharm Assoc 1979,3147-55
合成路线图解说明:

Hydrazine hydrate (I) is added dropwise under stirring to ethyl acetoacetate (II), which has been heated to 140 C, water and ethanol formed in the reaction are distilled off, and the mixture is heated at reflux. Upon completion of the reaction, the mixture is allowed to stand at room temperature, and the solid thus separated is collected and recrystallized from ethanol to obtain the title compound.

合成路线图解说明:

Suspension of 3-methyl-2-pyrazolin-5-one (I) is added dropwise under stirring to ethyl acetoacetate (II), which has been heated to 140 C, water and ethanol formed in the reaction are distilled off, and the mixture is heated at reflux. Upon completion of the reaction, the mixture is allowed to stand at room temperature, and the solid thus separated is collected and recrystallized from ethanol to obtain the title compound.

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