Alaptide, VUFB-15754, CPA, c(Acp-Ala)-药物合成数据库

【药物名称】Alaptide, VUFB-15754, CPA, c(Acp-Ala)

化学结构式(Chemical Structure):

参考文献No.	396
标题:	2,5-Piperazinedione derivs
作者:	Kasafirek, E.; Vanzura, J.; Krejci, I.; Krepelka, J.; Dlabac, A.; Valchar, M. (SPOFA - United Pharmaceutical Works)
来源:	CS 231227; GB 2127807

合成路线图解说明: The condensation of methyl 1-aminocyclopentane-1-carboxylate (I) with N-benzyloxycarbonyl-alanine (II) by the mixed anhydride method gives methyl 1-(benzyloxycarbonyl-alanyl)aminocyclopentane-1-carboxylate (III). Debenzylation of (III) by hydrogenation with H2 over Pd/C in methanol followed by a cyclization reaction in refluxing toluene yields alaptide.

参考文献No.	127620
标题:	ALAPTIDE
作者:	R醖l, S.; Kasaf韗ek, E.; Krejc? I.
来源:	Drugs Fut 1990,15(5),445

合成路线图解说明: The condensation of methyl 1-aminocyclopentane-1-carboxylate (I) with N-benzyloxycarbonyl-alanine (II) by the mixed anhydride method gives methyl 1-(benzyloxycarbonyl-alanyl)aminocyclopentane-1-carboxylate (III). Debenzylation of (III) by hydrogenation with H2 over Pd/C in methanol followed by a cyclization reaction in refluxing toluene yields alaptide.