【药物名称】KME-4
化学结构式(Chemical Structure):
参考文献No.42026
标题:3,5-di-Tert-butylstyrene derivatives, salts thereof and pharmaceutical compositions containing the same as an active ingredient
作者:Katsumi, I.; et al. (Kaneka Corp.)
来源:CA 1187505; EP 0057882; US 4431656
合成路线图解说明:

By a Wittig condensation between 3,5-di-tert-butyl-4-hydroxybenzaldehyde (I) and a triphenylphosphorenylidene butyrolactone (II) in hot DMSO.

参考文献No.42031
标题:Anti-inflammatory, analgesic and antipyretic pharmaceutical composition
作者:Katsumi, I.; et al. (Kaneka Corp.)
来源:CA 1167767; EP 0057881; US 4440784
合成路线图解说明:

By a Wittig condensation between 3,5-di-tert-butyl-4-hydroxybenzaldehyde (I) and a triphenylphosphorenylidene butyrolactone (II) in hot DMSO.

参考文献No.49912
标题:KME-4
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1986,11(8),655
合成路线图解说明:

By a Wittig condensation between 3,5-di-tert-butyl-4-hydroxybenzaldehyde (I) and a triphenylphosphorenylidene butyrolactone (II) in hot DMSO.

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