Sodium azodisalicylate, Azodisal disodium, Olsalazine sodium, CJ-91B, di-5-ASA, ADS, Dipentum-药物合成数据库

【药物名称】Sodium azodisalicylate, Azodisal disodium, Olsalazine sodium, CJ-91B, di-5-ASA, ADS, Dipentum

化学结构式(Chemical Structure):

参考文献No.	42020
标题:	Method and intermediates fo preparing high purity 3,3'-azo-bis-(6-hydroxybenzoic acid)
作者:	Agback, K.H.; Nygren, A.S. (Pharmacia & Upjohn AB)
来源:	EP 0036636; JP 56154445; US 4528367

合成路线图解说明: The diazotation of methyl-5-amino-2-hydroxybenzoate (I) with NaNO2 and HCl gives the cor responding diazonium salt (II), which is coupled with methyl 2-hydroxybenzoate (III) to afford the corresponding azobenzene (IV). Finally, this compound is hydrolyzed with boiling 1N NaOH.

参考文献No.	49733
标题:	Olsalazine sodium
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1986,11(1),30

合成路线图解说明: The diazotation of methyl-5-amino-2-hydroxybenzoate (I) with NaNO2 and HCl gives the cor responding diazonium salt (II), which is coupled with methyl 2-hydroxybenzoate (III) to afford the corresponding azobenzene (IV). Finally, this compound is hydrolyzed with boiling 1N NaOH.