Droxicam, E-3128, Drogelon, Ferpan, Ombolan-药物合成数据库

【药物名称】Droxicam, E-3128, Drogelon, Ferpan, Ombolan

化学结构式(Chemical Structure):

参考文献No.	45876
标题:	A chlorobenzhydryl piperazine derivative
作者:	Milani, C.; Carminati, G.M.; Sovera, A. (3M Pharmaceuticals)
来源:	DE 2950378

合成路线图解说明: By condensation of 3-carbethoxy-4-hydroxy-2-methyl-2H-1,2 benzothiazine 1,1-dioxide (III) vvith 2 pyridylisocyanate (II) obtained in situ by decom position of 2-phenoxycarbonylaminopyridine (I).

合成路线图解说明: By chlorination of acid (I) and subsequent esterification with the aminoalcohol (II).

参考文献No.	49712
标题:	Droxicam
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1986,11(10),835

合成路线图解说明: By condensation of 3-carbethoxy-4-hydroxy-2-methyl-2H-1,2 benzothiazine 1,1-dioxide (III) vvith 2 pyridylisocyanate (II) obtained in situ by decom position of 2-phenoxycarbonylaminopyridine (I).