Benzyl Benzoate
C14H12O2 212.24
Benzoic acid, phenylmethyl ester;
Benzyl benzoate
[120-51-4].
(ben' zil ben' zoe ate).
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C14H12O2 212.24
Benzoic acid, phenylmethyl ester;
Benzyl benzoate
[120-51-4].DEFINITION
Benzyl Benzoate contains NLT 99.0% and NMT 100.5% of C14H12O2.
IDENTIFICATION
ASSAY
• Procedure
Sample:
2 g of Benzyl Benzoate
Analysis:
Transfer the Sample to a conical flask fitted with a reflux condenser. Add 50.0 mL of 0.5 N alcoholic potassium hydroxide VS, and boil gently for 1 h. Cool, add phenolphthalein TS, and titrate with 0.5 N hydrochloric acid VS. Perform a blank determination (see Titrimetry 
541
). Each mL of 0.5 N alcoholic potassium hydroxide is equivalent to 106.1 mg of Benzyl Benzoate (C14H12O2).
541). Each mL of 0.5 N alcoholic potassium hydroxide is equivalent to 106.1 mg of Benzyl Benzoate (C14H12O2).
Acceptance criteria:
99.0%–100.5%
IMPURITIES
• Limit of Aldehydes
Sample solution:
Transfer 10.0 g to a 125-mL conical flask containing 50 mL of alcohol and 5 mL of hydroxylamine hydrochloride solution (3.5 in 100), mix, and allow to stand for 10 min.
Analysis:
Add 1 mL of bromophenol blue TS, and titrate with 0.1 N sodium hydroxide VS to a light green endpoint. Perform a blank determination, and match the color of the endpoint with that of the titrated Sample solution.
Acceptance criteria:
The net volume of 0.1 N sodium hydroxide consumed does not exceed 0.50 mL (0.05% as benzaldehyde).
SPECIFIC TESTS
• Specific Gravity 841:
1.116–1.120
841:
1.116–1.120
• Congealing Temperature 651:
Congelation may be brought about by the addition of a fragment of previously congealed Benzyl Benzoate when the temperature has reached the expected congealing temperature.
651:
Congelation may be brought about by the addition of a fragment of previously congealed Benzyl Benzoate when the temperature has reached the expected congealing temperature.
Acceptance criteria:
NLT 18.0
• Refractive Index 831:
1.568–1.570 at 20
831:
1.568–1.570 at 20
• Acidity:
Add 2 drops of phenolphthalein TS to 25 mL of alcohol, and add 0.020 N sodium hydroxide until a pink color is produced. Add 5.0 g of Benzyl Benzoate, and titrate with 0.020 N sodium hydroxide.
Acceptance criteria:
NMT 1.5 mL of 0.020 N sodium hydroxide is required to restore the pink color.
ADDITIONAL REQUIREMENTS
• Packaging and Storage:
Preserve in tight, well-filled, light-resistant containers, and avoid exposure to excessive heat.
• USP Reference Standards 11
11
USP Benzyl Benzoate RS 
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Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Behnam Davani, Ph.D., M.B.A.
Senior Scientific Liaison 1-301-816-8394 |
(SM12010) Monographs - Small Molecules 1 |
| Reference Standards | RS Technical Services 1-301-816-8129 rstech@usp.org |
USP35–NF30 Page 2331