Tropicamide
284.35Benzeneacetamide, N-ethyl-
-(hydroxymethyl)-N-(4-pyridinylmethyl)-, (±)-.
(±)-N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide
[1508-75-4].» Tropicamide contains not less than 99.0 percent and not more than 101.0 percent of C17H20N2O2, calculated on the dried basis.
Packaging and storage—
Preserve in tight, light-resistant containers.
Identification—
Loss on drying 
731
—
Dry about 500 mg, accurately weighed, in vacuum over phosphorus pentoxide at 80
for 4 hours: it loses not more than 0.5% of its weight.
731—
Dry about 500 mg, accurately weighed, in vacuum over phosphorus pentoxide at 80 for 4 hours: it loses not more than 0.5% of its weight.
Heavy metals, Method II 231:
0.002%.
231:
0.002%.
Assay—
Dissolve about 750 mg of Tropicamide, accurately weighed, in 80 mL of glacial acetic acid, add 4 drops of crystal violet TS, and titrate with 0.1 N perchloric acid VS to a blue-green endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 28.44 mg of C17H20N2O2.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
| Monograph | Feiwen Mao, M.S.
Scientist 1-301-816-8320 |
(MDOOD05) Monograph Development-Ophthalmics Oncologics and Dermatologicals |
| Reference Standards | Lili Wang, Technical Services Scientist 1-301-816-8129 RSTech@usp.org |
USP32–NF27 Page 3823