Octoxynol 9
Poly(oxy-1,2-ethanediyl),
-(octylphenyl)-
-hydroxy-.
Polyethylene glycol mono(octylphenyl) ether
[9002-93-1].» Octoxynol 9 is an anhydrous liquid mixture consisting chiefly of monooctylphenyl ethers of polyethylene glycols, corresponding to the formula:
C8H17C6H4(OCH2CH2)nOH
in which the average value of n is about 9.
Packaging and storage—
Preserve in tight containers.
USP Reference standards 
11
—
USP Octoxynol 9 RS.
11—
USP Octoxynol 9 RS.
Identification, Infrared Absorption 197F, on undried specimen.
197F, on undried specimen.
Cloud point—
Weigh 1.00 g into a 250-mL beaker, and add 99 g of water. Dissolve completely by careful heating, while stirring at a constant slow speed with a small-propeller-blade stirrer. Center a thermometer vertically in the solution, and heat rapidly until the entire solution becomes cloudy, then raise the temperature 10
. Remove the source of heat, continue stirring, and record the temperature at which the solution becomes sufficiently clear to permit seeing the entire thermometer bulb plainly: the cloud point is between 63 and 69.
. Remove the source of heat, continue stirring, and record the temperature at which the solution becomes sufficiently clear to permit seeing the entire thermometer bulb plainly: the cloud point is between 63 and 69.
Hydroxyl value 401:
between 85 and 101.
401:
between 85 and 101.
Water, Method I 921:
not more than 0.5%.
921:
not more than 0.5%.
Residue on ignition 281:
not more than 0.4%.
281:
not more than 0.4%.
Heavy metals 231:
0.002%.
231:
0.002%.
Free ethylene oxide—
Octoxynol 9 meets the requirements for Free ethylene oxide under Nonoxynol 9 (see USP monograph). In performing the test, substitute the term “Octoxynol 9” for “Nonoxynol 9” wherever it occurs. The limit is 5 ppm.
Limit of dioxane—
It meets the requirements for Limit of dioxane under Nonoxynol 9 (see USP monograph).
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
Chromatographic Column—
| Topic/Question | Contact | Expert Committee |
| Monograph | Hong Wang, Ph.D.
Scientist 1-301-816-8351 |
(EM205) Excipient Monographs 2 |
| Reference Standards | Lili Wang, Technical Services Scientist 1-301-816-8129 RSTech@usp.org |
USP32–NF27 Page 1289
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.