C2H3Cl3O2 165.40

1,1-Ethanediol, 2,2,2-trichloro-.
Chloral hydrate [302-17-0].

Packaging and storage— Preserve in tight containers.

Identification— Transfer to a 125-mL conical flask a portion of a solution in water equivalent to about 1 mg of chloral hydrate, and add water to bring the volume to about 10 mL. Add 10 mL of 1-ethylquinaldinium iodide solution (15 in 1000), which has been filtered through a 0.45-µm filter. Add 60 mL of isopropyl alcohol, 5 mL of an aqueous 0.1 M monoethanolamine solution, and 15 mL of water. Mix, and heat in a water bath at 60 for 15 minutes: a blue color develops.

Acidity— A 1 in 20 solution in alcohol does not at once redden moistened blue litmus paper.

Residue on ignition 281: not more than 0.1%.

Chloride 221— To a 1 in 10 solution in alcohol add a few drops of silver nitrate TS: any opalescence produced does not exceed that of a control containing 0.10 mL of 0.020 N hydrochloric acid (0.007%).

Readily carbonizable substances 271— Shake 500 mg, at intervals of 5 minutes during 1 hour, with 5 mL of sulfuric acid TS in a glass-stoppered cylinder that previously has been rinsed with sulfuric acid TS, and transfer the mixture to a comparison vessel: the mixture has no more color than Matching Fluid P.

Assay— Dissolve about 4 g of Chloral Hydrate, accurately weighed, in 10 mL of water, add 30.0 mL of 1 N sodium hydroxide VS, and allow the mixture to stand for 2 minutes. Add a few drops of phenolphthalein TS, and titrate the residual alkali at once with 1 N sulfuric acid VS. Each mL of 1 N sodium hydroxide corresponds to 165.4 mg of C2H3Cl3O2.

Topic/Question	Contact	Expert Committee
Monograph	Ravi Ravichandran, Ph.D. Senior Scientist 1-301-816-8330	(MDPP05) Monograph Development-Psychiatrics and Psychoactives

USP32–NF27 Page 1883

CHLORAL HYDRATE

Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.