| 异名/同义词 | AUTOLOGOUS CD4+/CD8+ ENRICHED T LYMPHOCYTES DERIVED FROM LEUKAPHERESIS MATERIAL, TRANSDUCED WITH A NON-REPLICATING MURINE STEM CELL VIRUS (MSCV)-DERIVED GAMMA RETROVIRAL VECTOR, ENCODING CODON-OPTIMISED FOLLICLE-STIMULATING HORMONE (FSH) (SUBUNITS FSH.BETA. AND CG.ALPHA., LINKED BY A GLYCINE/SERINE SPACER), PRECEDED BY THE FSH.BETA. SIGNAL PEPTIDE, AND FUSED TO A CD8.ALPHA. HINGE AND TRANSMEMBRANE DOMAIN, A 4-1BB CO-STIMULATORY DOMAIN AND A CD3.ZETA. SIGNALLING DOMAIN, UNDER CONTROL OF THE MOLONEY MURINE LEUKEMIA VIRUS (MMLV) LTR PROMOTER. THE VECTOR ALSO HAS LONG TERMINAL REPEATS (LTRS) DERIVED FROM MSCV AND AN EXTENDED PACKAGING SIGNAL (.PSI.+) DERIVED FROM MMLV AND HAS A SPLICE ACCEPTOR SEQUENCE IMMEDIATELY UPSTREAM OF THE START CODON. A KOZAK SEQUENCE PRECEDES THE TRANSGENE.
LIRALTAGENE AUTOLEUCEL
LIRALTAGENE AUTOLEUCEL [INN]
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