| 异名/同义词 | DNA (RECOMBINANT TUMOR-SELECTIVE REPLICATING ONCOLYTIC HUMAN ADENOVIRUS 5 VECTOR VCN-01 TRANSCRIPTION FACTOR E2F-BINDING BOXES PLUS TRANSCRIPTION FACTOR SP1-BINDING BOX-CONTAINING PROMOTER 415 PLUS HUMAN ADENOVIRUS 5 GENE E1A-.DELTA.24 PLUS HUMAN HYALURONIDASE PH-20 SOLUBLE FORM-SPECIFYING)
KKTK DOMAIN OF THE FIBER SHAFT WITH AN INTEGRIN-BINDING, TUMOUR-SELECTIRECOMBINANT, REPLICATION-COMPETENT ONCOLYTIC HUMAN ADENOVIRUS TYPE 5 (AD5) VECTOR, ENCODING HUMAN HYALURONIDASE PH-20 (SPERM ADHESION MOLECULE 1 (SPAM1) SOLUBLE FORM), UNDER THE CONTROL OF THE ADENOVIRUS MAJOR LATE PROMOTER VIA INSERTION OF THE PIIIA SPLICE ACCEPTOR AND A KOZAK SEQUENCE. GENETIC MODIFICATIONS OF THE VIRAL GENOME ALSO INCLUDE THE INSERTION OF FOUR E2F-RESPONSIVE SITES ALONG WITH ONE EXTRA SP-1 TRANSCRIPTION FACTOR BINDING SITE TO CONTROL EXPRESSION OF THE VIRAL EARLY REGION 1A (E1A) GENE, A 24 BASE PAIR DELETION IN THE E1A GENE, AND THE REPLACEMENT OF THE VE RGDK MOTIF
VCN 01 [WHO-DD]
VCN-01
VCN-01 (ZABILUGENE ALMADENOREPVEC) IS A RECOMBINANT TUMOR-SELECTIVE REPLICATING ONCOLYTIC VIRUS DERIVED FROM HUMAN ADENOVIRUS 5. VCN-01 CONTAINS 4 GENETIC MODIFICATIONS WITH RESPECT TO THE WILD-TYPE VIRUS (HAD5): I) A MODIFIED E1A PROMOTER WITH E2F AND SP1-BINDIN BOXES (PROMOTER 415); II) THE DELECTION E1A-.DELTA.24 (24 BASE PAIR DELETION IN THE E1A GENE); III)THE REPLACEMENT OF THE KKTK DOMAIN IN THE ADENOVIRUS FIBER PROTEIN BY THE RGDK AMINO ACID SEQUENCE; IV) AND ENCODES THE SOLUBLE FORM OF THE HUMAN SPERM HYALURONIDASE (PH20) TRANSCRIPTION UNIT
ZABILUGENE ALMADENOREPVEC
ZABILUGENE ALMADENOREPVEC [INN]
ZABILUGENE ALMADENOREPVEC [USAN]
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