美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Oxycodone HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Oxycodone HCl	Tablet (Extended Release)			Refer to USP			2016/03/17
Oxycodone HCl/ Naloxone HCl	Tablet (Extended Release)	II (Paddle)	50	Simulated Gastric Fluid [SGF, pH 1.2] without enzyme	900	0.25, 0.5, 1, 2, 4, 6, 8, 10 and 12 hours	2016/12/22
Oxymorphone HCl	Tablets			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Oxymorphone HCl	Tablet (Extended Release)	II (Paddle) with sinker	50	45 mM Phosphate Buffer, pH 4.5	900	1, 2, 4, 6, 8 and 10 hours	2014/02/14
Ozanimod HCl	Capsule			Refer to FDA's Dissolution Guidance, 2018			2022/05/12
Pacritinib Citrate	Capsule	II (Paddle) with sinker	75	0.08 M HCl/0.034 M NaCl, pH 1.2	900	5, 10, 15 and 30	2023/05/18
Palbociclib	Tablet	II (Paddle)	75	0.1 N HCl	900	10, 15, 20, 30 and 45	2021/08/19
Palbociclib	Capsule	II (Paddle) with sinker	50	0.1 N HCl	900	10, 15, 20, 30 and 45	2016/03/17
Paliperidone	Tablet (Extended Release)	II (Paddle)	50	Modified SGF, pH 1.0 [NaCl (0.2% w/w) in 0.0825N HCl]	500	1, 2, 4, 6, 8, 12, 14, 18 and 24 hours	2009/08/27
Paliperidone Palmitate	Intramuscular Suspension (Extended Release)			Develop a method to characterize in vitro release			2026/03/25
Palonosetron HCl	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Palovarotene	Capsule	II (Paddle) with sinkers	50	5 mM Phosphate buffer, pH 8.0 with 0.5% SLS	900	5, 10, 15, 30, 45 and 60	2024/11/01
Pancrelipase	Capsule (Delayed Release)			Refer to USP			2016/03/17
Pancrelipase	Tablet	II (Paddle)	50	Phosphate Buffer, pH 4.5	900	10, 20, 30, 45 and 60	2016/06/02
Panobinostat Lactate	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Pantoprazole Sodium	Delayed Release Granules for Oral Suspension	II (Paddle)	100	Acid Stage: 0.1 N Hydrochloric Acid; Buffer Stage: 0.05 M Tribasic Sodium Phosphate (Add 250 mL of 0.2 mM Tribasic Sodium Phosphate after completion of acid stage); pH 6.8 (Method B)	Acid stage: 750; Buffer stage: 1000	Acid stage: 60, 90 and 120; Buffer stage: 10, 20, 30, 45 and 60	2009/10/30
Pantoprazole Sodium	Tablet (Delayed Release)			Refer to USP			2009/07/21
Paricalcitol	Capsule	I (Basket)	100	4 mg/mL (0.4%) Lauryldimethylamine N-oxide (LDAO)	500	20, 30, 45, 60	2007/06/18
Paromomycin Sulfate	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02