美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Nifurtimox	Tablet	II (Paddle)	100	Acetate Buffer, pH 4.5 with 1.0 % Sodium Dodecyl Sulfate (SDS) (for 30 mg strength) and 1.5 % SDS (for 120 mg strength)	900	10, 20, 30, 60 and 75	2022/07/07
Nilotinib HCl	Capsule	I (Basket)	100	0.1 N HCl	1000	10, 15, 20, 30 and 45	2024/02/05
Nilotinib Hydrochloride Monohydrate	Capsule	I (Basket)	100	0.1 N HCl	1000	10, 15, 30 and 45	2009/10/30
Nilotinib Tartrate	Tablet	II (Paddle)	75	pH 6.8 Buffer with 1.25% CTAB	1000	5, 10, 15, 20, 30, 45 and 60	2026/01/28
Nilutamide	Tablet			Develop a dissolution method			2009/05/20
Nimodipine	Capsule			Develop a dissolution method			2023/09/15
Nintedanib Esylate	Capsule	II (Paddle) with sinker	100	0.1 N HCl	900	10, 15, 20, 30, 45 and 60	2015/09/03
Niraparib	Capsule	II (Paddle) with sinker	50	Tier 1: 0.08M Sodium Acetate Buffer, pH 4.0; Tier 2: 0.08M Sodium Acetate Buffer, pH 4.0 containing pepsin (750,000 units/L)	900	10, 15, 20, 30, 45 and 60	2017/11/02
Niraparib Tosylate	Tablet	II (Paddle)	60	0.1 M Citrate buffer, pH 4.6	900	5, 10, 15, 20, 25, 30 and 45	2024/02/05
Nirmatrelvir (NIR); Ritonavir (RIT)	Tablet (copackage)	II (Paddle)	75	NIR: 0.05 M Sodium Phosphate, pH 6.8 with 0.2% Sodium Dodecyl Sulfate; RIT: Refer to USP	900	15, 20, 30, 45 and 60	2024/08/05
Nirogacestat Hydrobromide	Tablet	II (Paddle)	75	pH 1.2 HCl buffer	500	5, 10, 15, 20, 30, 45 and 60	2025/09/08
Nisoldipine	Tablet (Extended Release)	II (Paddle) with option to use a sinker	50	HCl with SLS (32.5 ± 0.1 g Sodium Lauryl Sulfate in 6489 mL of purified water containing 17.0 mL HCl, pH adjusted to 1.20 ± 0.05 with HCl)	900	1, 4, 8, 12, 15, 18 and 24 hours	2009/04/02
Nitazoxanide	Tablet	II (Paddle)	75	Phosphate buffer at pH 7.5 with 6% hexadecyltrimethyl ammonium bromide, bath temperature at 25ºC	900	10, 20, 30, 45, 60	2007/01/03
Nitazoxanide	Oral Suspension	II (Paddle	100	Phosphate buffer at pH 7.5 with 6% hexadecyltrimethyl ammonium bromide, bath temperature at 25ºC	900	10, 20, 30, 45 and 60	2010/10/21
Nitisinone	Tablet	II (Paddle)	50	Phosphate Buffer, pH 6.8	2 mg tablets: 500 mL; 5 mg and 10 mg tablets: 900 mL	10, 15, 20, 30, 45, 60, 75 and 90	2018/02/15
Nitisinone	Capsule	II (Paddle) with sinker	50	Phosphate Buffer, pH 6.8	1000	5, 10, 15, 20, 30 and 45	2017/11/02
Nitisinone	Suspension	II (Paddle)	50	pH 1.2 HCl Buffer (degassed)	1000	10, 15, 20, 30 and 45	2016/12/22
Nitrofurantoin	Capsule			Refer to USP			2009/04/02
Nitrofurantoin	Suspension	II (Paddle)	50	Phosphate Buffer, pH 7.2	900	15, 30, 60, 120 and 180	2009/04/02
Nitroglycerin	Tablet (Sublingual)	II (Paddle)	50	Phosphate Buffer, pH 6.5	500	1, 3, 5, 8, and 10	2010/01/15