美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Nelfinavir Mesylate	Powder for Suspension	II (Paddle)	50	0.1 N HCl	900	5, 10, 15, 20, 30, and 45	2007/09/13
Neomycin Sulfate	Tablet	II (Paddle)	50	0.05 M Phosphate Buffer, pH 6.8	900	15, 30, 45 and 60	2008/01/14
Nepafenac	Ophthalmic Suspension			Develop a method to characterize in vitro release			2014/08/14
Netupitant/Palonosetron HCl	Capsule	II (Paddle)	Netupitant:100; Palonosetron: 75	Netupitant: 0.07M Phosphate buffer pH 6.8 containing 1% sodium SDS ; Palonosetron: 0.01 N HCl	Netupitant: 900; Palonosetron: 500	Netupitant: 10, 20, 30, 45, 60 and 75; Palonosetron: 5, 10, 15, 20, 30 and 45	2015/09/03
Nevirapine	Tablet (Extended Release)	I (Basket)	75	0.04 M Sodium phosphate buffer pH 6.8 containing 2% sodium lauryl sulfate	900	1, 2, 3, 4, 5, 6, 8, 10, 12, 16 and 20 hours	2013/01/31
Nevirapine	Suspension	II (Paddle)	25	0.1 N HCl	900	10, 20, 30, 45 and 60	2004/02/11
Nevirapine	Tablet			Refer to USP			2007/09/13
Niacin	Tablet (Extended Release)			Develop a dissolution method			2023/09/15
Niacin/Simvastatin	Tablet (Extended Release)	Simvastain: I (10 mesh rotating Basket)	100	Niacin: Develop a dissolution method; Simvastatin: 0.5 % SDS in 0.01 M Sodium Phosphate, pH 7.0	900	Simvastatin: 10, 20, 30, 45 and 60	2023/09/15
Nicardipine HCl	Capsule	II (Paddle)	50	0.033 M Citric Acid Buffer, pH 4.5	900	10, 20, 30 and 45	2004/02/11
Nicardipine HCl	Capsule (Extended Release)	II (Paddle)	50	0.1 N HCl	1000	0.5 , 2 and 6 hours	2008/07/14
Nicotine	Film, Transdermal (Extended Release)			Develop a dissolution method			2024/01/03
Nicotine Polacrilex	Lozenge (Mini)	III (Reciprocating Cylinder)	20 dpm	Phosphate buffer pH 7.4	250	15, 30, 45, 60 and 90	2017/03/09
Nicotine Polacrilex	Lozenge	I (Basket)	100	Phosphate Buffer, pH 7.4	900	0.5, 1, 2, 3, 6 and 8 hours	2010/12/23
Nicotine Polacrilex	Chewing Gum	Chewing Machine as desribed in European Pharmacopoeia (2.9.25)	60 cycles (chews) per minute	Phosphate Buffer, pH 7.4 or or any other appropriate buffer and conditions	20	5, 10, 20 and 30	2012/01/05
Nifedipine	Capsule			Refer to USP			2011/03/03
Nifedipine	Tablet (Extended Release)			Develop a dissolution method			2024/01/03
Nifurtimox	Tablet	II (Paddle)	100	Acetate buffer pH 4.5 with 1% sodium dodecyl sulfate (SDS) for 30 mg strength and 1.5 % SDS for 120 mg strength	900	15, 30, 45, 60, 90 and 120	2023/02/09
Nifurtimox	Tablet	II (Paddle)	100	Acetate Buffer, pH 4.5 with 1.0 % Sodium Dodecyl Sulfate (SDS) (for 30 mg strength) and 1.5 % SDS (for 120 mg strength)	900	10, 20, 30, 60 and 75	2022/07/07
Nilotinib HCl	Capsule	I (Basket)	100	0.1 N HCl	1000	10, 15, 20, 30 and 45	2024/02/05